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The Organic Chemistry of Drug Design and Drug Action

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This book provides a new approach to the teaching and understanding of medicinal chemistry. It is a survey of basic principles of drug design and drug action in which the concepts are presented from a physical organic chemistry perspective so that the design, development, and mechanisms of action and metabolism of drugs can be rationally understood. The reader is then able This book provides a new approach to the teaching and understanding of medicinal chemistry. It is a survey of basic principles of drug design and drug action in which the concepts are presented from a physical organic chemistry perspective so that the design, development, and mechanisms of action and metabolism of drugs can be rationally understood. The reader is then able to apply these principles to any specific classes of drugs of interest and to understand how these drugs might act at a molecular level.KEY FEATURES • Provides an organic and synthetic chemist's perspective of how drugs are designed and how they function • Teaches organic chemists and biochemists the fundamentals of drug design and drug action using drugs as examples • No prior knowledge of biochemistry, pharmacology, or physiology is assumed • Extensive use of references to the primary and secondary literature for more in depth reading about all concepts • Extensive use of structures, schemes, and figures to illustrate points • Problem sets and answers are included for each topic • Informal but clear writing style so practicing chemists and undergraduates can easily understand the concepts presentedRichard B. Silverman is professor has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry, has been awarded 21 patents, and has invented a drug that is under consideration for commercialization.


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This book provides a new approach to the teaching and understanding of medicinal chemistry. It is a survey of basic principles of drug design and drug action in which the concepts are presented from a physical organic chemistry perspective so that the design, development, and mechanisms of action and metabolism of drugs can be rationally understood. The reader is then able This book provides a new approach to the teaching and understanding of medicinal chemistry. It is a survey of basic principles of drug design and drug action in which the concepts are presented from a physical organic chemistry perspective so that the design, development, and mechanisms of action and metabolism of drugs can be rationally understood. The reader is then able to apply these principles to any specific classes of drugs of interest and to understand how these drugs might act at a molecular level.KEY FEATURES • Provides an organic and synthetic chemist's perspective of how drugs are designed and how they function • Teaches organic chemists and biochemists the fundamentals of drug design and drug action using drugs as examples • No prior knowledge of biochemistry, pharmacology, or physiology is assumed • Extensive use of references to the primary and secondary literature for more in depth reading about all concepts • Extensive use of structures, schemes, and figures to illustrate points • Problem sets and answers are included for each topic • Informal but clear writing style so practicing chemists and undergraduates can easily understand the concepts presentedRichard B. Silverman is professor has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry, has been awarded 21 patents, and has invented a drug that is under consideration for commercialization.

30 review for The Organic Chemistry of Drug Design and Drug Action

  1. 5 out of 5

    Laura

    The movie was definitely better.

  2. 5 out of 5

    Elizabeth

    I heard Richard B. Silverman at a seminar he gave for the Pharmacology Department, "Selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative inhibitors" (thought I probably would have just left the title at "Selective neuronal nitric oxide synthase inhibitors", or, better yet, "Inhibitors that are selective for nNOS over eNOS or iNOS"). I heard Richard B. Silverman at a seminar he gave for the Pharmacology Department, "Selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative inhibitors" (thought I probably would have just left the title at "Selective neuronal nitric oxide synthase inhibitors", or, better yet, "Inhibitors that are selective for nNOS over eNOS or iNOS").

  3. 5 out of 5

    Ken Knott

  4. 4 out of 5

    Rand

  5. 5 out of 5

    Ray

  6. 4 out of 5

    Nazia

  7. 4 out of 5

    Lynda

  8. 5 out of 5

    Algirdas Brukštus

  9. 5 out of 5

    Daniel Morales

  10. 4 out of 5

    afeisha carter

  11. 5 out of 5

    Ash Jogalekar

  12. 4 out of 5

    Karen

  13. 4 out of 5

    Daniel A

  14. 4 out of 5

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  15. 5 out of 5

    Jwafula

  16. 5 out of 5

    Jason Blanchet

  17. 4 out of 5

    Jasmin

  18. 4 out of 5

    Jutti Levita

  19. 5 out of 5

    Gaurav Pawar

  20. 5 out of 5

    Yuvraj

  21. 4 out of 5

    Suhaib

  22. 4 out of 5

    Honey Khan

  23. 4 out of 5

    Matej Ošlaj

  24. 4 out of 5

    Epilepsymine

  25. 5 out of 5

    Michael

  26. 5 out of 5

    Eric

  27. 4 out of 5

    Lisa Ahlberg

  28. 5 out of 5

    Abdullah

  29. 4 out of 5

    Deepak Marathe

  30. 5 out of 5

    Ahmed Salah

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