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The LDN Book: How a Little-Known Generic Drug — Low Dose Naltrexone — Could Revolutionize Treatment for Autoimmune Diseases, Cancer, Autism, Depression, and More

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Low Dose Naltrexone (LDN) holds the potential to help millions of people suffering from various autoimmune diseases and cancers, and even autism, chronic fatigue, and depression, find relief. Administered off-label in small daily doses (0.5 to 4.5 mg), this generic drug is extremely affordable and presents few known side effects. So why has it languished in relative medica Low Dose Naltrexone (LDN) holds the potential to help millions of people suffering from various autoimmune diseases and cancers, and even autism, chronic fatigue, and depression, find relief. Administered off-label in small daily doses (0.5 to 4.5 mg), this generic drug is extremely affordable and presents few known side effects. So why has it languished in relative medical obscurity? The LDN Book explains the drug’s origins, its primary mechanism, and the latest research from practicing physicians and pharmacists as compiled by Linda Elsegood of The LDN Research Trust, the world’s largest LDN charity organization with over 19,000 members worldwide. Featuring ten chapters contributed by medical professionals on LDN’s efficacy and two patient-friendly appendices, The LDN Book is a comprehensive resource for doctors, pharmacists, and patients who want to learn more about how LDN is helping people now, and a clarion call for further research that could help millions more.


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Low Dose Naltrexone (LDN) holds the potential to help millions of people suffering from various autoimmune diseases and cancers, and even autism, chronic fatigue, and depression, find relief. Administered off-label in small daily doses (0.5 to 4.5 mg), this generic drug is extremely affordable and presents few known side effects. So why has it languished in relative medica Low Dose Naltrexone (LDN) holds the potential to help millions of people suffering from various autoimmune diseases and cancers, and even autism, chronic fatigue, and depression, find relief. Administered off-label in small daily doses (0.5 to 4.5 mg), this generic drug is extremely affordable and presents few known side effects. So why has it languished in relative medical obscurity? The LDN Book explains the drug’s origins, its primary mechanism, and the latest research from practicing physicians and pharmacists as compiled by Linda Elsegood of The LDN Research Trust, the world’s largest LDN charity organization with over 19,000 members worldwide. Featuring ten chapters contributed by medical professionals on LDN’s efficacy and two patient-friendly appendices, The LDN Book is a comprehensive resource for doctors, pharmacists, and patients who want to learn more about how LDN is helping people now, and a clarion call for further research that could help millions more.

30 review for The LDN Book: How a Little-Known Generic Drug — Low Dose Naltrexone — Could Revolutionize Treatment for Autoimmune Diseases, Cancer, Autism, Depression, and More

  1. 4 out of 5

    Sarah Evan

    The science of how LDN works presented in this book is way over my head, but I appreciated the summary of how this medication has off-label uses that have been studied with very positive results. It is infuriating that the studies have not been done with larger sample sizes as the small studies, case studies, and friends have had amazing results for IBD and other autoimmune diseases with this fairly benin drug. I also appreciated the chapter about how to talk to your doctor about using this medi The science of how LDN works presented in this book is way over my head, but I appreciated the summary of how this medication has off-label uses that have been studied with very positive results. It is infuriating that the studies have not been done with larger sample sizes as the small studies, case studies, and friends have had amazing results for IBD and other autoimmune diseases with this fairly benin drug. I also appreciated the chapter about how to talk to your doctor about using this medication, as well as a chapter from a compounding pharmacist who has learned about and processed orders for LDN (which is sometimes very low dose!)

  2. 4 out of 5

    JenniferD

    this is a tricky one to rate... while the potential presented in the book is exciting to consider, studies and testing to the standards of industry are not plentiful. it's always worth being cautious when something sounds too good to be true, and especially when vulnerable populations - like the chronically ill - are the audience. having said that, i was glad to read the book -- i had heard about LDN treatment a few years ago, and was recently reminded of it by a friend. i think it is worth me d this is a tricky one to rate... while the potential presented in the book is exciting to consider, studies and testing to the standards of industry are not plentiful. it's always worth being cautious when something sounds too good to be true, and especially when vulnerable populations - like the chronically ill - are the audience. having said that, i was glad to read the book -- i had heard about LDN treatment a few years ago, and was recently reminded of it by a friend. i think it is worth me discussing with two of my doctors, to hear their take. luckily, one of them focused on pharmacology too, in addition to their primary specialty, so i feel he will be well-informed on this off-label use of naltrexone.

  3. 5 out of 5

    Marella Mylet

    This is literally the best book I've ever read in my life. I tore through it and used up an entire brand new highlighter marking things that were important and exciting. READ IT. This is literally the best book I've ever read in my life. I tore through it and used up an entire brand new highlighter marking things that were important and exciting. READ IT.

  4. 5 out of 5

    Robin

    This book provides a lot of solid information backed by studies to show the MANY off label uses for LDN (Low Dose Naltrexone). A lot of this information in the book was very technical, and even with multiple re-reads I still found parts of it were over my head. Still, it was so fascinating to me there were time I would read a section, pause to google research, pause to wiki definition/meaning, pause to check ldnscience for descriptions, and read again. I like to joke that it's the best book that This book provides a lot of solid information backed by studies to show the MANY off label uses for LDN (Low Dose Naltrexone). A lot of this information in the book was very technical, and even with multiple re-reads I still found parts of it were over my head. Still, it was so fascinating to me there were time I would read a section, pause to google research, pause to wiki definition/meaning, pause to check ldnscience for descriptions, and read again. I like to joke that it's the best book that I'll never fully understand. I felt the best chapter was the one on how to talk to your doctor. Even with all that information about LDN that I brought to them, my local doctors refused to prescribe it. My pain clinic doctor wanted to prescribe it for me, but LDN isn't on the list of allowed medications at the group practice where he works (it's "being considered", but that could take months or longer). I turned to LDNScience.org where there's a section that lists prescribing doctors - since none were near me, I had to turn to telemedicine and consult with ldndoctor (both dot-com and on Facebook) to get my prescription. It hasn't arrived from the compounding pharmacy yet, but I am excited to try it.

  5. 5 out of 5

    Beth

    Excellent and informative book about low dose naltrexone. I read the beginning chapters of the book but skimmed through or skipped the subsequent chapters. The most relevant part of the book, I found to be the explanation of this physicians discovery and treatment of her patients with LDN. She devoted chapters to using the medication for multiple sclerosis, ulcerative colitis and other autoimmune diseases. The LDN book was written in 2014, since then the FDA has approved the use of LDN for Fibro Excellent and informative book about low dose naltrexone. I read the beginning chapters of the book but skimmed through or skipped the subsequent chapters. The most relevant part of the book, I found to be the explanation of this physicians discovery and treatment of her patients with LDN. She devoted chapters to using the medication for multiple sclerosis, ulcerative colitis and other autoimmune diseases. The LDN book was written in 2014, since then the FDA has approved the use of LDN for Fibromyalgia. Under that umbrella is chronic pain and osteoarthritis. This is my particular interest. There are articles on the Internet about the specific use of LDN for chronic pain. It is miracle drug that most of the medical community is unaware of. Therefore this book is a very important documentation of the amazing benefits of the use of LDN that have yet to be discovered by most. Thank you Dr Elsegood for writing this book. I do hope more read and discover.

  6. 4 out of 5

    C.A. Gray

    Very interesting. I've heard for years about how LDN is essentially useful for every kind of chronic illness, but because I didn't understand the mechanism of action and because it claimed to be useful for everything, I never thought of it for any one condition and therefore almost never prescribed it. This book explains both the mechanisms we know and the mechanisms speculated, and describes how they can be useful for individual illnesses including various kinds of autoimmunity, depression, and Very interesting. I've heard for years about how LDN is essentially useful for every kind of chronic illness, but because I didn't understand the mechanism of action and because it claimed to be useful for everything, I never thought of it for any one condition and therefore almost never prescribed it. This book explains both the mechanisms we know and the mechanisms speculated, and describes how they can be useful for individual illnesses including various kinds of autoimmunity, depression, and cancer. I'm far more inclined to prescribe and endorse it now, especially because its benefits come from the rebound action of the body rather than the primary action of the drug--meaning it actually helps the body to heal itself (pretty much the same mechanism of action of homeopathy, hydrotherapy, and most other naturopathic therapies.) This is also the reason that there are very few side effects to speak of -- the side effects are the whole reason it's prescribed!

  7. 5 out of 5

    Mwalkes

    This is a book that is so important I was not able to finish it before sharing it. My friend did the same. She ended up purchasing another for me. Because LDN is not a financial shining star, it will never be marketed to its full potential for helping people. It is up to people like the author of this book, and you and I, to get this information to people who need it. My advice - get it and share it.

  8. 4 out of 5

    Wendy

    Very interesting. Would love to try for fibromyalgia and rls but it is daunting to think about trying to get a doctor who will let you.

  9. 5 out of 5

    Adam

    Well written/edited with a large bibliography and many footnotes for further investigation. It's a good starter for learning about this topic. Well written/edited with a large bibliography and many footnotes for further investigation. It's a good starter for learning about this topic.

  10. 4 out of 5

    Yycdaisy

    This is a compilation of informative articles on the use of LDN for various conditions. Somewhat repetitive as the different authors re-hash the basics, however one can skip to the article that covers the condition of interest.

  11. 5 out of 5

    Denise Hlavka

    Unbelievable information!

  12. 4 out of 5

    Carie

    Hard to read without having a medical educational background but still informative enough to the average person.

  13. 4 out of 5

    Linda Elsegood

    This book is a very good guide for people with Autoimmune Diseases and Cancer to learn about LDN. (Low Dose Naltrexone)

  14. 4 out of 5

    Astacia

  15. 5 out of 5

    Jen

  16. 4 out of 5

    Maria

  17. 5 out of 5

    Kelly Doyle

  18. 4 out of 5

    Kaye

  19. 4 out of 5

    Candie

  20. 5 out of 5

    Virginia

  21. 4 out of 5

    Melgilreath

  22. 4 out of 5

    Amanda Steffens

  23. 5 out of 5

    kimberly

  24. 4 out of 5

    Kristina Malek

  25. 5 out of 5

    Robert H Hunter

  26. 4 out of 5

    Ven Sio

  27. 4 out of 5

    Pearl

  28. 4 out of 5

    Sigrid

  29. 5 out of 5

    YORAM ZEVNOVATY BRAUN.

  30. 5 out of 5

    Patricia Bugalski

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